4.6 Article

Dissecting miRNA facilitated physiology and function in human breast cancer for therapeutic intervention

Journal

SEMINARS IN CANCER BIOLOGY
Volume 72, Issue -, Pages 46-64

Publisher

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2020.05.017

Keywords

Exosomal miRNA; Breast cancer; DNA methyltransferase; Cell signaling; Breast cancer treatment

Categories

Funding

  1. NIT-Rourkela under the Institute Research Scheme, NIT-Rourkela
  2. DST-INSPIRE
  3. CSIR, Govt. of India
  4. DST-women Scientist Scheme, DST-India
  5. Department of Bio-Technology (Government of India) [BT/PR21318/MED/12/742/2016]
  6. Department of Science and Technology-SERB (Government of India) [EMR/2016/007034]

Ask authors/readers for more resources

miRNAs play a key role in regulating biological processes and development in animals and plants, they are involved in post-transcriptional gene regulation by preventing translation. Aberrant regulation of miRNAs is associated with cancer development, understanding the biogenesis and function of miRNAs could offer potential therapeutic implications for treating breast cancers.
MicroRNAs (miRNAs) are key epigenomic regulators of biological processes in animals and plants. These small non coding RNAs form a complex networks that regulate cellular function and development. MiRNAs prevent translation by either inactivation or inducing degradation of mRNA, a major concern in post-transcriptional gene regulation. Aberrant regulation of gene expression by miRNAs is frequently observed in cancer. Overexpression of various 'oncomiRs' and silencing of tumor suppressor miRNAs are associated with various types of human cancers, although overall downregulation of miRNA expression is reported as a hallmark of cancer. Modulations of the total pool of cellular miRNA by alteration in genetic and epigenetic factors associated with the biogenesis of miRNA machinery. It also depends on the availability of cellular miRNAs from its store in the organelles which affect tumor development and cancer progression. Here, we have dissected the roles and pathways of various miRNAs during normal cellular and molecular functions as well as during breast cancer progression. Recent research works and prevailing views implicate that there are two major types of miRNAs; (i) intracellular miRNAs and (ii) extracellular miRNAs. Concept, that the functions of intracellular miRNAs are driven by cellular organelles in mammalian cells. Extracellular miRNAs function in cell-cell communication in extracellular spaces and distance cells through circulation. A detailed understanding of organelle driven miRNA function and the precise role of extracellular miRNAs, pre- and post-therapeutic implications of miRNAs in this scenario would open several avenues for further understanding of miRNA function and can be better exploited for the treatment of breast cancers.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available