Journal
RNA BIOLOGY
Volume 18, Issue 1, Pages 47-63Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2020.1790140
Keywords
RNA-binding proteins; long non-coding RNA; glioma
Categories
Funding
- Natural Science Foundation of China [81872503, 81872073, 81802514]
- Liaoning Science and Technology Plan Project [2017225020, 2015225007]
- Project of Key Laboratory of Neuro-oncology in Liaoning Province [112-2400017005]
- central government of Liaoning Province [2017011553-301]
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In glioma, NCBP3/SNHG6 inhibits GBX2 transcription in a PRC2-dependent manner, facilitating the malignant progression of gliomas.
RNA-binding proteins (RBPs) are significantly dysregulated in glioma. In this study, we demonstrated the upregulation of Nuclear cap-binding subunit 3 (NCBP3) in glioma tissues and cells. Further, knockdown of NCBP3 inhibited the malignant progression of glioma. NCBP3 directly bound to small nucleolar RNA host gene 6 (SNHG6) and stabilized SNHG6 expression. In contrast, the gastrulation brain homeobox 2 (GBX2) transcription factor was downregulated in glioma tissues and cells. SNHG6 inhibited GBX2 transcription by mediating the H3K27me3 modification induced by polycomb repressive complex 2 (PRC2). Moreover, GBX2 decreased the promoter activities and downregulated the expression of the flotillin protein family 1 (FLOT1) oncogene. In conclusion, NCBP3/SNHG6 inhibits GBX2 transcription in a PRC2-dependent manner to facilitate the malignant progression of gliomas.
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