Journal
REVIEWS IN FISH BIOLOGY AND FISHERIES
Volume 30, Issue 4, Pages 569-586Publisher
SPRINGER
DOI: 10.1007/s11160-020-09614-y
Keywords
Teleost fish; Gut health; Intestinal mucosal barrier; Damage; Gut microbiota; Cell death
Categories
Funding
- National Natural Science Foundation of China [31702354, 31602169, 31672294, 31572633]
- Beijing earmarked fund for Modern Agro-industry Technology Research System [SCGWZJ 20191104-4]
- Innovation Capability Support Program of Shaanxi [2018TD-021]
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The intestinal mucosal barrier plays a critical role in the maintenance of host health. In farmed teleost fish, the intestinal epithelium is challenged by a number of factors, leading to damage of the intestinal mucosal barrier. The pathogenesis of intestinal mucosal barrier damage in most farmed teleost fish has been associated with cell death, mainly including apoptosis, pyroptosis, necroptosis as well as secondary injury by cell lysis. However, the mechanisms behind intestinal mucosal barrier damage are not well studied. Here we summarized the factors causing damage of intestinal mucosal barrier in fish. Further we discussed the intracellular and interstitial signaling cascades, with special emphasis on cell death that potentially accelerates the progression of intestinal injury. Deeper understanding of the mechanisms of intestinal mucosal barrier damage may facilitate the development of potential intervention strategies for intestinal diseases in farmed teleost fish.
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