Journal
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume 105, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2020.110013
Keywords
Interleukin 6; Tumor necrosis factor alpha; C-reactive protein; Childhood maltreatment; Grey matter volume; Source-based morphometry
Funding
- National Health and Medical Research Council of Australia (NHMRC) Enabling Grant [386500]
- Pratt Foundation
- Ramsay Health Care
- Viertel Charitable Foundation
- Schizophrenia Research Institute
- 2016 Early-Career Researcher Project Grant from the Society for Mental Health Research (SMHR)
- NHMRC [630471, 1081603, 1059660, 1156072]
- Macquarie University's ARC Centre of Excellence in Cognition and its Disorders [CE110001021]
- NHMRC's R.D. Wright Biomedical Career Development Fellowship [1061875]
- Matthew Flinders Fellowship, Flinders University, Australia
- Australian Government Research Training Program (RTP) Scholarship
- Edward C Dunn Foundation Postgraduate Scholarship
- National Health and Medical Research Council of Australia [1081603, 1061875] Funding Source: NHMRC
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Elevated levels of systemic inflammation are consistently reported in both schizophrenia and bipolar-I disorder, and are associated with childhood trauma exposure. Systemic inflammation may be associated with grey matter changes in individuals with psychosis, and these relationships may be partially and differentially moderated by childhood trauma exposure according to diagnosis.
Background: Elevated levels of systemic inflammation are consistently reported in both schizophrenia (SZ) and bipolar-I disorder (BD), and are associated with childhood trauma exposure. We tested whether childhood trauma exposure moderates associations between systemic inflammation and brain morphology in people with these diagnoses. Methods: Participants were 55 SZ cases, 52 BD cases and 59 healthy controls (HC) who underwent magnetic resonance imaging. Systemic inflammation was measured using a composite z-score derived from serum concentrations of interleukin 6, tumor necrosis factor alpha and C-reactive protein. Indices of grey matter volume covariation (GMC) were derived from independent component analysis. Childhood trauma was measured using the Childhood Trauma Questionnaire (CTQ Total score). Results: A series of moderated moderation analyses indicated that increased systemic inflammation were associated with increased GMC in the striatum and cerebellum among all participants. Severity of childhood trauma exposure moderated the relationship between systemic inflammation and GMC in one component, differently among the groups. Specifically, decreased GMC in the PCC/precuneus, parietal lobule and postcentral gyrus, and increased GMC in the left middle temporal gyrus was associated with increased systemic inflammation in HC individuals exposed to high (but not low or average) levels of trauma and in SZ cases exposed to low (but not average or high) levels of trauma, but not in BD cases. Conclusions: Increased systemic inflammation is associated with grey matter changes in people with psychosis, and these relationships may be partially and differentially moderated by childhood trauma exposure according to diagnosis.
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