Journal
PROGRESS IN CARDIOVASCULAR DISEASES
Volume 63, Issue 4, Pages 398-406Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pcad.2020.06.005
Keywords
Bicuspid aortic valve; Genetics; Aortic aneurysm; Congenital heart disease
Categories
Funding
- National Heart, Lung and Blood Institute (NIH) [R01HL137028]
Ask authors/readers for more resources
Bicuspid aortic valve (BAV) is the most common congenital heart defect, found in up to 2% of the population and associated with a 30% lifetime risk of complications. BAV is inherited as an autosomal dominant trait with incomplete penetrance and variable expressivity due to a complex genetic architecture that involves many interacting genes. In this review, we highlight the current state of knowledge about BAV genetics, principles and methods for BAV gene discovery, clinical applications of BAV genetics, and important future directions. (c) 2020 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available