Journal
POLYMER
Volume 202, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2020.122733
Keywords
Hyaluronic acid; Silk fibroin; Hydrogel
Categories
Funding
- Cooperative Research Program for Agriculture Science and Technology Development of the Rural Development Administration, Republic of Korea [PJ01226801]
- Ministry of Trade, Industry & Energy (MOTIE, Korea) [1062525]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10062525] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Hyaluronic acid (HA) is highly biocompatible and is therefore utilized in various medical fields. Recent efforts have achieved a wide variety of HA-based hydrogel fabrications and their potent applications in tissue engineering. Nevertheless, HA hydrogels have limitations in physical property control due to the nature of HA. In this study, a hybrid hydrogel was formed with hyaluronic acid-methacrylate (HAMA) and silk fibroin-methacrylate (SFMA) via photopolymerization, followed by physical cross-linking of silk fibroin (SF) chains. The photopolymerization was completed within 5 min under UV irradiation, although the gel point increased with an increase in SFMA content. By ethanol treatment, the SF domain formed beta-sheet structures, resulting in double network in HA/SF hybrid hydrogel. As a result, the shear modulus of the HA/SF hybrid hydrogel significantly increased with an increase of SFMA content, while the swelling ratio decreased. In addition, the HA/SF hybrid hydrogel exhibited gel-sol transition under shear stress, suggesting potential application as an injectable material.
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