Journal
POLYHEDRON
Volume 185, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2020.114585
Keywords
Cyclopeptide; Stability constants; Dinuclear complexes; Potentiometric titration; Spectroscopic methods
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Funding
- Wroclaw Medical University, Poland [STM.D080.20.020]
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The interest in cyclic peptide research has increased in the last decade. These compounds are resistant to enzymatic degradation and possess a more rigid scaffold than their linear analogues. This paper presents the results of combined potentiometric and spectroscopic studies on the coordination properties of hetero-site cyclopeptide (CDP) with the c(HHKHHPHDHKHP) sequence. Thermodynamic stability constants for ligands and complex forms have been determined in a system with a double excess of copper ions, i.e. with a molar ratio to ligand L:Cu(II) of 1:2. The interaction was characterised by UV-Vis, CD, EPR and ESI-MS methods over a wide pH range. CDP is a good chelator for divalent metal ions, it creates mono, di- and trinuclear complexes with copper(II) ions over a wide range of pH. It was found that promotion of di-copper(II) complexes is connected with a higher flexibility of the cyclopeptide chain. (C) 2020 Elsevier Ltd. All rights reserved.
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