Journal
PHYTOTHERAPY RESEARCH
Volume 35, Issue 1, Pages 424-441Publisher
WILEY
DOI: 10.1002/ptr.6817
Keywords
bone quality; Fructus Ligustri Lucidi; medicated serum; ovariectomized rats; primary osteoblasts; Wnt/beta-catenin
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Funding
- National Key Research and Development Plan [2018YFC2002500]
- Program for Innovative Research Team in University [IRT_17R11]
- Beijing Municipal Natural Science Foundation [7172126]
- Canadian Institute of Health Research
- National Natural Science Foundation of China [81874373, 81673837]
- Program for QiHuang Scholar (Sihua Gao) in State Administration of Traditional Chinese Medicine
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Fructus Ligustri Lucidi (FLL) may preserve bone quality through induction of canonical Wnt/beta-catenin signaling and activation of osteoblastic bone formation, offering a potential new source of DKK1 or SOST inhibitors in protection against osteoporosis.
Fructus Ligustri Lucidi(FLL) has been preclinically and clinically used to treat musculoskeletal diseases. However, whether and how FLL affect the canonical Wnt/beta-catenin signaling in the management of osteoporosis remains largely unknown. To this end, ovariectomized (OVX) rats and primary osteoblasts were administrated with FLL aqueous extract and medicated serum, respectively. Supplement of FLL to OVX rats maintains bone quality by attenuating the reduction in bone mineral density, strength and microstructure. The maintenance may be associated with upregulating the expression of insulin-like growth factor-1, osteoprotegerin, phospho (p)-low-density lipoprotein receptor-related protein 6, p-glycogen synthase kinase 3 beta (GSK3 beta), beta-catenin, Runx2 and c-Myc, and downregulating the expressions of sclerostin (SOST), dickkopf-related protein 1 (DKK1), GSK3 beta and p-beta-catenin in rat femurs and tibias. In addition, the medicated serum promotes osteoblastic bone formation through activation of Wnt/beta-catenin signaling via inhibition of DKK1 and SOST overexpression. Salidroside may be one of the active ingredients in FLL that are beneficial for bone homeostasis. In summary, our results suggest that FLL may preserve bone quality through induction of canonical Wnt/beta-catenin signaling via inhibition of DKK1 and SOST overexpression. And FLL may offer a new source of the DKK1 or SOST inhibitors in protection against osteoporosis.
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