Journal
PHYTOCHEMISTRY REVIEWS
Volume 20, Issue 1, Pages 343-365Publisher
SPRINGER
DOI: 10.1007/s11101-020-09702-8
Keywords
Vincamine; Tabersonine; Semi-synthesis; Indole alkaloids
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This review summarizes the main strategies for the total synthesis of vincamine and congeners, and presents a semi-synthesis method of (+)-vincamine using tabersonine as the starting material. Characterization and quantification of main impurities are discussed, along with reporting HPLC conditions, structural elucidation, and NMR data for four of them.
This review summarizes the main strategies aimed at the total synthesis of vincamine and congeners. Then, our contribution in this field is presented: we describe (+)-vincamine semi-synthesis using tabersonine as starting material. Characterization and quantification of the main impurities are discussed, and HPLC conditions, structural elucidation and NMR data of four of them are reported.
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