Journal
PHYTOCHEMISTRY LETTERS
Volume 38, Issue -, Pages 39-45Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2020.05.002
Keywords
Galium brunneum; Rubiaceae; beta-Sitosterol; Hydroperoxysterols; Cucurbitacins; NMR
Categories
Funding
- MIUR-ITALY PRIN2015 Top-down and bottom-up approach in the development of new bioactive chemical entities inspired on natural products scaffolds [2015MSCKCE_004]
- Faculte de Medecine, Universite de Batna-2
- Faculte des Sciences de la Matiere, Universite de Batna-1 (Algeria)
Ask authors/readers for more resources
The liposoluble extract of Galium brunneum aerial parts from North-eastern Algeria was chemically investigated. The EtOAc soluble portion contained a series of glycosyl cucurbitacins and sterols including three new glucosyl hydroperoxy sterols 1 - 3 among other phenolic components whereas the BuOH soluble fraction was dominated by glycosyl derivatives of flavonoids, iridoids and lignans, according to the chemistry reported in the literature for the genus Galium. The structure of new oxidized sterols 1 - 3 was determined by spectroscopic methods as well as by comparison with related known metabolites. Selected main compounds from both extracts, which revealed moderate antibacterial activities, were tested for their growth inhibitory properties against Gram-positive and Gram-negative bacteria. This is the first report of cucurbitacins in plants of genus Galium .
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available