Journal
PHYTOCHEMISTRY LETTERS
Volume 37, Issue -, Pages 33-36Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2020.03.009
Keywords
Artemisia myriantha Wall. ex Bess; Asteraceae; Sesquiterpene lactones; Cytotoxic activity
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Funding
- National Natural Science Foundation of China [81373294, 81222051, 81303253]
- National Key Technology R&D Program New Drug Innovation of China [2017ZX09101003-008-003]
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Chemical exploration of Artemisia myriantha Wall. ex Bess (Asteraceae) aerial parts afforded one new seco-guaianolide (1) and one new germacranolide (2). Structure elucidation of the new compounds was un-ambiguously performed based on HRESIMS, 1D and 2D NMR spectroscopic analyses. The two new compounds exhibited in vitro strong cytotoxic activities against human cancer cell lines HCT-8 with IC50 values of 0.76 and 0.28 mu M, respectively.
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