Journal
PHYTOCHEMISTRY
Volume 174, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2020.112360
Keywords
Reutealis trisperma; Euphorbiaceae; Anti-HIV activity; Tigliane diterpenoids; Crotignoids L similar to Q
Categories
Funding
- National Key R&D Program of China [2019YFC1711000]
- National Natural Science Foundation of China [81273486]
- Doctoral Program of Higher Education, China [2012007113011]
- Development Project of Shanghai Peak Disciplines-Integrative Medicine [20180101]
- National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA [AI033066]
Ask authors/readers for more resources
Bioassay-guided fractionation of the n-butanol extract from the branches and leaves of Reutealis trisperma resulted in the isolation of six undescribed (crotignoids L similar to Q) together with two known (12-deoxyphorbol-13-hexadecanoate and 12-deoxyphorbol-13-myristate) tigliane diterpenoids. Their structures, especially the absolute configurations, were determined from extensive spectroscopic studies, including 2D NMR spectra, CD data analysis and electronic circular dichroism (ECD) calculations. All isolates were tested for anti-HIV activity against HL4-3 virus in MT4 cells. Except for crotignoid Q, the remaining seven tigliane diterpenoids exhibited potent anti-HIV activity with IC50 values ranging from 0.0023 to 4.03 mu M.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available