Journal
PHYTOCHEMISTRY
Volume 174, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2020.112337
Keywords
Isatis tinctoria L.; Brassicaceae; Indole alkaloids; Isatisindigoticanines H and I; Isatindigosides F and G; Nitric oxide inhibition
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Funding
- National Natural Science Foundation of China [81573571, 81673570]
- Excellent Academic Leaders Program of Shanghai [16XD1403500]
- programs of the High Level University Innovation Team
- Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine
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Four undescribed sulfur-containing indole alkaloids, isatisindigoticanines H, I and isatindigosides F, G along with three known analogues were obtained from Isatis tinctoria L. roots. Isatisindigoticanines H and I contained an unusual 1-(thiazol-4-yl)butane-1,2,3,4-tetraol moiety while isatindigosides F and G possessed a new 3- [3-(1H-indole-2-yeazet-2-yl]-1H-indole skeleton. The putative biosynthetic pathways of isatisindigoticanines H, I and isatindigosides F, G are proposed. The isolated compounds showed nitric oxide inhibitory effects with IC50 values ranging from 4.3 to 70.3 mu M.
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