Journal
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
Volume 30, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.pdpdt.2020.101687
Keywords
Ultra high quantum yield CQDs; Targeted cancer imaging; HeLa cancer cell; MCF-7 cancer cell; Fluorescence imaging
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Funding
- Jiroft University of Medical Sciences [p-94-34]
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Folic acid functionalized carbon quantum dots (FA-CQDs) with ultrahigh quantum yield (50 %) were synthesized by one-pot hydrothermal route using citric acid. The synthesized CQDs were characterized by fluorescence spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS) and X-ray diffraction. The cell viability of about 95% and 97% were obtained for MTT assay of the CQDs and FA-CQDs toward MCF-7 cells after 24 h of incubation respectively. The FA-CQDs were successfully applied for targeted imaging of ovarian cancer (type HeLa) and human breast adenocarcinoma (type MCF7) cells using fluorescence microscope.
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