Journal
PHARMACOLOGY & THERAPEUTICS
Volume 210, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2020.107523
Keywords
Air pollution; Diesel exhaust; Neurotoxicity; Oxidative stress; Neuro-inflammation; Neurodevelopmental disorders; Autism; Neurodegenerative diseases; Alzheimer's disease
Categories
Funding
- NIEHS [R01ES022949, R01ES028273, P30ES07033, T32ES007032, P42ES04696]
- NICHD [U54HD08091]
- University ofWashington
- Department of Environmental and Occupational Health Sciences at the University of Washington
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Recent extensive evidence indicates that air pollution, in addition to causing respiratory and cardiovascular diseases, may also negatively affect the brain and contribute to central nervous system diseases. Air pollution is comprised of ambient particulate matter (PM) of different sizes, gases, organic compounds, and metals. An important contributor to PM is represented by traffic-related air pollution, mostly ascribed to diesel exhaust (DE). Epidemiological and animal studies have shown that exposure to air pollution may be associated with multiple adverse effects on the central nervous system. In addition to a variety of behavioral abnormalities, the most prominent effects caused by air pollution are oxidative stress and neuro-inflammation, which are seen in both humans and animals, and are supported by in vitro studies. Among factors which can affect neurotoxic outcomes, age is considered most relevant. Human and animal studies suggest that air pollution may cause developmental neurotoxicity, and may contribute to the etiology of neurodevelopmental disorders, including autism spectrum disorder. In addition, air pollution exposure has been associated with increased expression of markers of neurodegenerative disease pathologies, such as alpha-synuclein or beta-amyloid, and may thus contribute to the etiopathogenesis of neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease. (C) 2020 Published by Elsevier Inc.
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