Journal
PHARMACOLOGICAL REVIEWS
Volume 72, Issue 3, Pages 639-667Publisher
AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
DOI: 10.1124/pr.119.019026
Keywords
-
Categories
Funding
- National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [R01-DK097075, R01-DK109574]
- NIH National Heart, Lung, and Blood Institute (NHLBI) [P0IHL114457, R01-HL109233, R01-HL119837, R01-HL133900]
- Texas Medical Center Digestive Diseases Center through NIH NIDDK [P30 DK056338]
- American Thoracic Society
- American Heart Association Career Development Award [19CDA34660279]
- American Lung Association Catalyst Award [CA-622265]
- Center for Clinical and Translational Sciences, McGovern Medical School Pilot Award [1UL1TR003167-01]
- American Cancer Society Research Scholar Grants [RSG-19-185-01-MPC]
- NIH National Cancer Institute (NCI) [R01 CA150153, P01 CA163205]
- NIH National Institute of Neurologic Disorders and Stroke (NINDS) [R01 NS064607]
- NIH NINDS [R01 NS104280]
Ask authors/readers for more resources
Cancer and organ injury-such as that occurring in the perioperative period, including acute lung injury, myocardial infarction, and acute gut injury -are among the leading causes of death in the United States and impose a significant impact on quality of life. MicroRNAs (miRNAs) have been studied extensively during the last two decades for their role as regulators of gene expression, their translational application as diagnostic markers, and their potential as therapeutic targets for disease treatment. Despite promising preclinical outcomes implicating miRNA targets in disease treatment, only a few miRNAs have reached clinical trials. This likely relates to difficulties in the delivery of miRNA drugs to their targets to achieve efficient inhibition or overexpression. Therefore, understanding how to efficiently deliver miRNAs into diseased tissues and specific cell types in patients is critical. This review summarizes current knowledge on various approaches to deliver therapeutic miRNAs or miRNA inhibitors and highlights current progress in miRNA-based disease therapy that has reached clinical trials. Based on ongoing advances in miRNA delivery, we believe that additional therapeutic approaches to modulate miRNA function will soon enter routine medical treatment of human disease, particularly for cancer or perioperative organ injury. Significance Statement-MicroRNAs have been studied extensively during the last two decades in cancer and organ injury, including acute lung injury, myocardial infarction, and acute gut injury, for their regulation of gene expression, application as diagnostic markers, and therapeutic potentials. In this review, we specifically emphasize the pros and cons of different delivery approaches to modulate microRNAs, as well as the most recent exciting progress in the field of therapeutic targeting of microRNAs for disease treatment in patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available