Journal
PATHOLOGY RESEARCH AND PRACTICE
Volume 223, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.prp.2020.152824
Keywords
IL-8; TNBC; Migration; Tumorigenesis
Categories
Funding
- National Natural Science Foundation of China [NSFC 31200971]
- Ministry of Science and Technology of YuZhong District, CQ [20150109]
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IL-8 plays a crucial role in the progression of TNBC, promoting tumor cell migration and growth, affecting cell cycle, and influencing the expression of certain cell cycle proteins.
Triple-negative breast cancer (TNBC) is a type of malignant and heterogeneous tumor in premenopausal females with ineffective therapeutic targets. IL-8 is one of the earliest discovered chemotaxis cytokines which expression is closely related to the progress of various cancers. Previous studies show that IL-8 determines the prognosis of TNBC patients, nevertheless how IL-8 influence the progress of TNBC is unclear. In our studies, we discovered that overexpression of IL-8 promotes TNBC cells (TNBCs) migration and tumor growth via the PI3K-Akt and MAPK signaling pathway. Cell-cycle of TNBCs arrest at S phase by overexpression of IL-8, however, there is no significant difference on the cell viability and cell apoptosis of TNBCs. Besides, overexpression of IL-8 result in the downregulation of E-cadherin and the upregulation of Cyclin B1 in MDA-MB-231 cells. Taken together, our results suggest that IL-8 plays a crucial role in the progress of TNBC, and it could be a novel therapeutic target of TNBC.
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