Journal
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
Volume 37, Issue 8, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppsc.202000143
Keywords
cancer therapy; La doping; manganese oxide; metal oxide sonosensitizers; sonodynamic therapy
Funding
- National Natural Science Foundation of China [81901758, 21802173]
- Science and Technology Planning Project of Guangdong Province [2018A050506028]
- Natural Science Foundation of Guangdong Province [2018A030310301]
- Fundamental Research Funds for the Central Universities [20ykpy171, 19lgpy146]
Ask authors/readers for more resources
Metal oxides hold great promise as robust sonosensitizers for sonodynamic therapy (SDT). However, they usually suffer from limited production yield of reactive oxygen species (ROS) due to the fast recombination of ultrasound-triggered electrons and holes. Herein, porous lanthanum (La)-doped MnO2(LMO) nanoparticles are firstly developed as promising sonosensitizers in SDT. The strategic introduction of La dopants greatly promotes the separation efficiency of ultrasound-triggered electrons and holes of MnO2, endowing them with significantly improved ROS yield. Consequently, the LMO with polyethylene glycol decoration exhibits good SDT activity toward breast cancer cells. This work highlights the doping strategy for the development of enhanced ROS production of metal oxide sonosensitizers for SDT.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available