Journal
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
Volume 37, Issue 9, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppsc.202000136
Keywords
coassembled nanoparticles; codelivery; mitochondrial targeting; nanocarriers; pillar[5]arene; silica; Au nanoparticle composites
Funding
- NRF from the Ministry of Science [2020R1A4A2002831, 2018R1A2B2003637]
- Next-Generation BioGreen 21 Program (SSAC), Rural development Administration, Korea [PJ013186052020]
- Rural Development Administration (RDA), Republic of Korea [PJ013186052020] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Coassembled nanoparticles composed of functionalized mesoporous silica and pillar[5]arene-appended Au nanoparticles obtained through the formation of a host-guest complex are designed and synthesized as a mitochondrial-selective dual-drug delivery system. A pyridinium-based ligand and fluorescein isothiocyanate are immobilized onto mesoporous silica to act as the mitochondria-targeting ligand and fluorescence tracker, respectively, of a material dubbed NP-3. Carboxylated pillar[5]arene-capped Au nanoparticles (CP-AuNPs) are fabricated by the templated reduction of Au3+. Interestingly, coassembled nanoparticles (NP-1) composed of doxorubicin (DOX) loaded NP-3 and CP-AuNPs are then prepared via the formation of a host-guest complex between the pyridinium-based ligand of NP-3 and the pillar[5]arene of CP-AuNPs. To demonstrate the effectiveness of NP-2 and NP-1 as mitochondrial targeting drug delivery systems, DOX and F16 are employed as model drugs. These drugs loaded onto NP-2 and CP-AuNPs, respectively, are selectively delivered to mitochondria, indicating the usefulness of NP-2 and CP-AuNPs as mitochondrial-specific drug-delivery carriers in cancer cells. More interestingly, the use of NP-1 is also associated with the selective accumulation of DOX and F16 in mitochondria. The selective mitochondrial-targeting of NP-1 is possible by NP-2 and F16 exposed to the cytoplasm, allowing the codelivery of the two drugs to the mitochondria.
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