Journal
PARASITOLOGY RESEARCH
Volume 119, Issue 8, Pages 2727-2731Publisher
SPRINGER
DOI: 10.1007/s00436-020-06746-9
Keywords
Genotyping; Mouse bioassay; Newborn; Virulence
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil [206740/2017-4]
- Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco (FACEPE) [IBPG-1358-5.05]
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We report a case of severe congenital toxoplasmosis that involved an atypicalT. gondiigenotype in a newborn baby from Alagoas state in Northeastern Brazil. A pregnant woman presented IgM and IgG anti-T. gondiiantibodies, as detected by the chemiluminescence immunoassay on the second trimester of pregnancy. A mouse bioassay was performed using umbilical cord blood and one isolate was obtained. The isolate was designated TgCTBrAL1 and genetic characterization revealed genotype ToxoDB #162. Genotype results of the rhoptry genes, ROP5 and ROP18, could predict the high virulence of the isolate in mice, which was confirmed by an in vivo virulence assay. This is the first report of generating aT. gondiiisolate from a newborn baby with congenital toxoplasmosis in Northeastern Brazil.
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