Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 24, Issue 8, Pages 1543-1548Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.0c00303
Keywords
chemistry in water; surfactant; amide coupling; scale up; environment sustainability
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Funding
- Novartis, Inc.
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The technology of surfactant chemistry is employed for amide bond construction via the reaction of acyl chlorides with amines in 2 wt % TPGS-750-M aqueous solution. Specifically, this highly efficient method enables a chromatography-free scalable process and recycling of the TPGS-750-M solution.
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