4.6 Article

Simple Synthesis of Amides via Their Acid Chlorides in Aqueous TPGS-750-M

Journal

ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 24, Issue 8, Pages 1543-1548

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.0c00303

Keywords

chemistry in water; surfactant; amide coupling; scale up; environment sustainability

Funding

  1. Novartis, Inc.

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The technology of surfactant chemistry is employed for amide bond construction via the reaction of acyl chlorides with amines in 2 wt % TPGS-750-M aqueous solution. Specifically, this highly efficient method enables a chromatography-free scalable process and recycling of the TPGS-750-M solution.

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