Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 24, Issue 10, Pages 2356-2361Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.0c00235
Keywords
hydrogen atom transfer; C-H functionalization; photocatalysis; decatungstate; flow photochemistry; process intensification
Categories
Funding
- China Scholarship Council (CSC)
- European Union [794072]
- Dutch Science Foundation (NWO) [14150]
- COST Action [CA15106]
- Marie Curie Actions (MSCA) [794072] Funding Source: Marie Curie Actions (MSCA)
Ask authors/readers for more resources
Tetrabutylammonium decatungstate (TBADT) has emerged as an efficient and versatile photocatalyst for hydrogen atom transfer (HAT) processes that enables the cleavage of both activated and unactivated aliphatic C-H bonds. Using a recently developed oscillatory millistructured continuous-flow photoreactor, investigations of a decatungstate-catalyzed C(sp(3))-H alkylation protocol were carried out, and the results are presented here. The performance of the reactor was evaluated in correlation to several chemical and process parameters, including residence time, light intensity, catalyst loading, and substrate/reagent concentration. In comparison with previously reported batch and flow protocols, conditions were found that led to considerably higher productivity, achieving a throughput up to 36.7 mmol/h with a residence time of only 7.5 min.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available