Journal
ORGANIC LETTERS
Volume 22, Issue 16, Pages 6628-6631Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02402
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Funding
- National Natural Science Foundation of China [21762021, 91853114]
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A novel ynamide-mediated synthesis of thionoesters and dithioesters is described. The selective addition reactions of various monothiocarboxylic acids with ynamide furnish alpha-thioacyloxyenamides, which undergo transesterification with nucleophilic -OH or -SH species to afford thionoesters and dithioesters, respectively. The broad substrate scope, mild reaction conditions, and excellent yields make this method an attractive synthetic approach to thionoesters and dithioesters.
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