Journal
ORGANIC LETTERS
Volume 22, Issue 16, Pages 6399-6403Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02208
Keywords
-
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada
- Canada Foundation for Innovation
- Innovation PEI
- Nautilus Biosciences CRODA
- Jeanne and Jean-Louis Le'vesque Foundation
Ask authors/readers for more resources
A meroterpenoid, guanahanolide A (1), was purified from a fermentation extract of Streptomyces sp. RKBH-B7. The planar structure of guanahanolide A (1) was elucidated by NMR spectroscopy, revealing a meroterpenoid comprised of an unprecedented sesterterpene skeleton. Upon determination of the relative configuration of 1 through X-ray crystallography, its absolute configuration was unambiguously assigned using Mosher ester analysis. Guanahanolide A (1) showed moderate cytotoxicity against human cancer cell lines MCF-7, HTB-26, and HCT-116.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available