Journal
ORGANIC LETTERS
Volume 22, Issue 15, Pages 5984-5989Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02080
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Funding
- National Natural Science Foundation of China [21971001, 21702001]
- Natural Science Foundation of Anhui Province [1808085MB47]
- Open fund for Discipline Construction, Institute of Physical Science and Information Technology, Anhui University
- Anhui University
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An efficient, photoredox-catalyst-free radical alkylation of quinoxalin-2(1H)-ones has been described. This reaction utilizes 4-alkyl-1,4-dihydropyridines (R-DHPs) as alkyl radical precursors and acetoxybenziodoxole (BI-OAc) as an electron acceptor to undergo single-electron transfer with photoexcited R-DHPs. The benign conditions allow for good compatibility in the scope of both quinoxalin-2(1H)-ones and R-DHPs. The synthetic value of the protocol was also demonstrated by the successful functionalization of natural products and drug-based complex molecules
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