Journal
ORGANIC LETTERS
Volume 22, Issue 14, Pages 5567-5571Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01927
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Funding
- National Natural Science Foundation of China [21772177]
- Natural Science Foundation of Zhejiang Province [LY19B020016]
- Fundamental Research Funds of Zhejiang Sci-Tech University [2019Q065]
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An FeCl3-mediated cascade coupling/decarbonylative annulation reaction for the efficient construction of 2-(trifluoromethyl)quinazolin-4(3H)-ones has been developed. This transformation employs readily available isatins and trifluoroace-timidoyl chlorides as the starting materials, providing a facile and practical route to diverse biologically relevant quinazolin-4(3H)one derivatives. A plausible reaction pathway has been proposed based on the mechanistic observations.
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