Journal
ORGANIC LETTERS
Volume 22, Issue 13, Pages 4995-5000Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01558
Keywords
-
Categories
Funding
- NSFC [21702136, 21871117, 21772076, 91956203]
- MOE
- MOST [2018ZX09711001-005-002]
- STCSM [19JC1430100]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
Ask authors/readers for more resources
A copper-catalyzed direct asymmetric coupling of C2 sterically-hindering-group-substituted indoles with quinone and naphthoquinone esters was developed by using the spirocyclic pyrrolidine oxazoline (SPDO) ligand, which was accomplished by metal catalysis for the first time. Diverse structures of axially chiral 3-arylindoles were obtained with good to high enantioselectivities in good to high yields. This protocol can be expanded to implement beta-coupling with naphthoquinone esters, providing an alternative way to prepare beta-substituted derivatives of both naphthols and naphthoquinones.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available