Journal
ORGANIC LETTERS
Volume 22, Issue 13, Pages 5005-5008Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01574
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Funding
- National Natural Science Foundation of China [21732002, 21672117]
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We have developed a protocol for catalyst- and additive-free alpha-alkylation reactions of glycine derivatives with diacyl peroxides, which proceed by a pathway involving addition of alkyl radicals to imine intermediates. The diacyl peroxide substrate acts as both alkylation agent and oxidizing agent, which means it is atom-economical. It was applied to various glycine derivatives, dipeptides, and a 3,4-dihydroquinoxalin-2(1H)-one derivative and could be carried out on a gram scale, indicating its utility for late-stage functionalization.
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