Journal
ORGANIC LETTERS
Volume 22, Issue 14, Pages 5695-5700Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02082
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Funding
- National Natural Science Foundation of China [21871198, 21674070]
- Major Research Project of the Natural Science of the Jiangsu Higher Education Institutions [19KJA360005]
- project of scientific and technologic infrastructure of Suzhou [SZS201708]
- PAPD
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Readily available zinc alkyl complexes showed good activity and regioselectivity in catalyzing hydroboration and hydrosilylation of N-heteroarenes. Hydroboration of benzo-fused N-heterocycles gave exclusive 1,2-addition products in 80-97% yields. Reactions of pyridines afforded a mixture of 1,2-, 1,4-, and 1,6-products in yields of 55-95%, with 1,2-dihydropyridine as the main product. Bis-hydrosilylation was observed for quinoline derivatives, generating bis-1,2-hydrosilylation products in 76-96% yields. Kinetic studies and control experiments were conducted to gain some insights into the reaction mechanism.
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