Journal
ORGANIC LETTERS
Volume 22, Issue 16, Pages 6394-6398Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02216
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Funding
- National Science Foundation of China [21602213, 21971228]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- China Postdoctoral Science Foundation [2017M622255]
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The first example of the Pd(II)-catalyzed enantioselective amination of aryl C-H bonds is reported. The key to the successful realization of this asymmetric catalytic transformation was the identification of mono-N-protected alpha-amino-O-methylhydroxamic acid (MPAHA) ligands, which promote reactivity under mild conditions and control enantioselectivity. The counteranions in the solvent medium, hexafluoroacetylacetate and acetate, were also found to play key roles in stereocontrol and reactivity enhancement.
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