Adropin as a potential mediator of the metabolic system-autonomic nervous system-chronobiology axis: Implementing a personalized signature-based platform for chronotherapy

Adropin is a peptide hormone, which plays a role in energy homeostasis and controls glucose and fatty acid metabolism. Its levels correlate with changes in carbohydrate-lipid metabolism, metabolic diseases, central nervous system function, endothelial function and cardiovascular disease. Both metabolic pathways and adropin are regulated by the circadian clocks. Here, we review the roles of the autonomic nervous system and circadian rhythms in regulating metabolic pathways and energy homeostasis. The beneficial effects of chronotherapy in various systems are discussed. We suggest a potential role for adropin as a mediator of the metabolic system-autonomic nervous system axis. We discuss the possibility of establishing an individualized adropin and circadian rhythm-based platform for implementing chronotherapy, and variability signatures for improving the efficacy of adropin-based therapies are discussed.

Automated summary

Adropin, a peptide hormone, plays a significant role in energy homeostasis and metabolic regulation, influenced by circadian rhythms. The autonomic nervous system and circadian clocks are crucial in regulating metabolic pathways and energy balance, with chronotherapy showing beneficial effects in various systems. There is potential for adropin to act as a mediator in the metabolic system-autonomic nervous system axis, with personalized adropin and circadian rhythm-based platforms for chronotherapy being discussed for enhancing treatment efficacy.