Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress

were then separated into 2 groups and supplemented with either LR-JB1 (TM) or placebo and re-evaluated after 4 weeks of continued CUMS. The LR-JB1 (TM) microbiotic diet restored these metabolites to levels previously observed in controls, while the placebo diet resulted in further significant decrease of glutamate, total choline, and tNAA. LR-JB1 (TM) treated animals also exhibited calmer and more relaxed behavior, as compared with placebo treated animals. In summary, significant cerebral biochemical downregulation of major brain metabolites following prolonged stress were measured in vivo using MRS, and these decreases were reversed using a microbiotic dietary supplement of LR-JB1 (TM), even in the presence of continued stress, which also resulted in a reduction of stress-induced behavior in a rat model of depressive-like disorder. (C) 2020 The Author(s). Published by Elsevier Inc.