Aloe veraand Honey Solution and Their Ethanolic Extraction Solution Could Act on Metastasis-Regulating Processes in Walker 256 Tumor Tissues In Vivo?

Research has shown that bothAloe veraand honey have anticancer and nutrition properties, including the inhibition of metastasis. In order to evaluate the effect of a solution ofAloe veraand honey (A) and their ethanolic fraction (F) on metastasis-regulating processes in primary tumors, Wistar rats were subcutaneously implanted with Walker 256 tumors and treated with A and F (670 mu l/kg by gavage, daily for 21 days). An analysis of the primary tumor tissues of these animals showed a decrease in N-cadherin expression in groups WA and WF, with a concomitant increase in E-cadherin expression in group WA compared to the control group. Cathepsin D activity was also decreased in the tumor tissues from groups WA and WF. In addition, the number of blood vessels and their diameter significantly reduced in tumor tissues from groups WA and WF compared to those from control group. UHPLC-ESI-MS/MS analysis of the samples A and F, suggested presence of molecules with verified antitumor activity, including caffeic acid, ferulic acid, mannose, aloin A, aloin B, pinocembrin, chrysin, and kaempferol. These data showed that treatment with A and F could reduce the metastatic propensity of tumors by modulating neoangiogenesis and the process of epithelial-to-mesenchymal transition.

Automated summary

Research has shown that treatment with a solution of Aloe vera and honey can reduce the metastatic propensity of tumors by modulating neoangiogenesis and the process of epithelial-to-mesenchymal transition. The analysis of the primary tumor tissues showed a decrease in N-cadherin expression and Cathepsin D activity in the treated groups, along with a decrease in blood vessel number and diameter. UHPLC-ESI-MS/MS analysis suggested the presence of molecules with verified antitumor activity in the Aloe vera and honey samples.