Journal
NEUROSCIENCE RESEARCH
Volume 170, Issue -, Pages 195-200Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2020.07.007
Keywords
Auto-Inhibition; N1; Prepulse inhibition; Sensory gating
Categories
Funding
- National Institute for Physiological Sciences [2019-619]
- Japan Society for the Promotion of Science [17K10296, 18K07619]
- Grants-in-Aid for Scientific Research [18K07619, 17K10296] Funding Source: KAKEN
Ask authors/readers for more resources
The study investigated the effects of a preceding decrease in sound pressure on the degree of inhibition of the subsequent Change-N1 amplitude, and found that any type of change in sound feature is inhibited by any type of preceding change stimulus.
Change-N1 peaking 90-180 ms after changes in a sound feature of a continuous sound is clearly attenuated by a preceding change stimulus (called a p spacing diaeresis repulse) spacing diaeresis . Here, we investigated the effects of a preceding decrease in sound pressure on the degree of inhibition of the subsequent Change-N1 amplitude. Using 100-Hz click train sounds, we obtained Change-N1s from 11 healthy volunteers. The two types of test stimuli were an abrupt 10-dB increase from the baseline (70 dB) and the insertion of a 0.45-ms inter-aural time difference in the middle of the sound. Three consecutive clicks at 30, 40, and 50 ms before the change onset that was used as a prepulse were weaker than the background by 5 or 10 dB. The Change-N1 elicited by the two test stimuli was attenuated more strongly by the weaker prepulse, which was not congruent with the theory that the inhibition of the subsequent sensory/sensory-motor processing depends on the sound pressure level of a prepulse. These results suggest that a change in any type of sound feature elicits a change-related response that is inhibited by any type of preceding change stimulus, which reflects auto-inhibition of the change-responding circuit. (c) 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available