The effects of transcranial direct current stimulation on corticospinal and cortico-cortical excitability and response variability: Conventional versus high-definition montages

Response variability following transcranial direct current stimulation (tDCS) highlights need for exploring different tDCS electrode montages. Corticospinal excitability (CSE), cortico-cortical excitability and intraindividual variability was compared following conventional and high-definition (HD) anodal (a-tDCS) and cathodal (c-tDCS) tDCS. Fifteen healthy males attended four sessions at-least one-week apart: conventional a-tDCS, conventional c-tDCS, HD-a-tDCS, HD-c-tDCS. TDCS was administered (1 mA, 10-minutes) over primary motor cortex (M1), via 6 x 4 cm active and 7 x 5 cm return electrodes (conventional tDCS) and 4 x 1 ring-electrodes 3.5 cm apart over M1 (HD-tDCS). For CSE, twenty-five single-pulse transcranial magnetic stimulation (TMS) peak-to-peak motor evoked potentials (MEP) were recorded at baseline, 0 minutes and 30-minutes post-tDCS. Twenty-five paired-pulse MEPs with 3-millisecond (ms) inter-pulse interval (IPI) and twenty-five at 10 ms assessed short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF). MEP standardised z-values standard deviations represented intra-individual variability. No significant changes in CSE from baseline were reported for all four interventions. No significant differences were reported in CSE between conventional and HD a-tDCS, but significant differences between conventional and HD c-tDCS 0-minutes post-tDCS. Conventional tDCS significantly reduced intra-individual variability compared to HD-tDCS for a-tDCS (0-minutes) and c-tDCS (30-minutes). No changes were reported for SICI/ICF. These novel findings of increased intra-individual variability following HD-tDCS, at the current stimulus parameters, highlight need for further nuanced research and refinement to optimise the HD-tDCS dosage-response relationship. (c) 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.

Automated summary

This study compared the effects of conventional and high-definition transcranial direct current stimulation on corticospinal excitability, cortico-cortical excitability and intra-individual variability under conventional and HD electrode montages. The results indicated that the two electrode montages had little effect on corticospinal excitability, but there was a significant difference in HD c-tDCS at 0 minutes post-stimulation. Conventional tDCS was more effective at reducing intra-individual variability compared to HD-tDCS.