Individual Subnuclei of the Rat Anterior Thalamic Nuclei Differently affect Spatial Memory and Passive Avoidance Tasks

The role of the anterior thalamic nuclei (ATN) has been proven in different learning and memory tasks. The ATN consist of three main subnuclei, the anterodorsal (AD), anteroventral (AV) and anteromedial (AM), which have different biological characteristics such as distinct circuitry, cell population and neurotransmitter content. The role of ATN subnuclei in learning and memory has been shown in several studies. However, their probable role in different phases of memory including acquisition, consolidation and retrieval are not still well-known. For this purpose, the effect of reversible inactivation of each ATN subnucleus on different memory phases in two behavioral tasks including passive avoidance (PA) and Morris water maze (MWM) was studied. Wister male rats were bilaterally implanted with cannulas above the AD, AV or AM subnucleus in separate experimental groups in order to inject lidocaine (4%) for their temporal inactivation or, equal volume of saline. Animals were trained in the behavioral tasks and different phases of memory were investigated. Our findings indicated that the AV inactivation strongly disrupts all memory phases in the MWM, and consolidation and retrieval phases in the PA tasks. The AM inactivation had no effect on acquisition of both tasks while it impaired the PA consolidation and MWM retrieval. However, the AD inactivation could not disrupt memory phases in the PA task but impaired the MWM retrieval. In conclusion, it seems that the ATN distinct subnuclei differently affect different phases of memory in these two tasks. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.