Journal
NEUROSCIENCE
Volume 448, Issue -, Pages 300-310Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2020.07.032
Keywords
neurometabolism; circadian; sleep; biosensor; solute transporters
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Funding
- National Institute of Aging [1R21AG050054-01A1]
- National Science Foundation CAREER Award [1553067]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1553067] Funding Source: National Science Foundation
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Aging is associated with reduced amplitude and earlier timing of circadian (daily) rhythms in sleep, brain function, and behavior. We examined whether age-related circadian dysfunction extends to the metabolic function of the brain, particularly in the prefrontal cortex (PFC). Using enzymatic amperometric biosensors, we recorded lactate concentration changes in the PFC in Young (7 mos) and Aged (19 mos) freely-behaving C57BL/6N male mice. Both Young and Aged mice displayed diurnal and circadian rhythms of lactate, with the Aged rhythm slightly phase advanced. Under constant conditions, the Aged rhythm showed a reduced amplitude not seen in the Young mice. We simultaneously observed a relationship between arousal state and PFC lactate rhythm via electroencephalography, which was modified by aging. Finally, using RT-qPCR, we found that aging affects the daily expression pattern of Glucose Transporter 1 (GLUT-1). (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
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