Journal
NEUROLOGICAL RESEARCH
Volume 42, Issue 8, Pages 693-702Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/01616412.2020.1782079
Keywords
Schisandrin B; neuroprotection; ischemia; reperfusion injury; inflammation; apoptosis
Categories
Funding
- ational College Students Innovation and Entrepreneurship Training Program (CN) [2018153]
- Nantong science and technology plan project [MSZ18102]
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It has been established that poor outcomes in ischemic stroke patients are associated with the post-reperfusion inflammatory response and up-regulation of TLR4. Therefore, suppression of the TLR4 signaling pathway constitutes a potential neuroprotective therapeutic strategy. Schisandrin B, a compound extracted fromSchisandra chinensis, has been shown to possess anti-inflammatory and neuroprotective properties. However, the mechanism remains unclear. In the present study, the therapeutic effect of schisandrin B was assessed following cerebral ischemia and reperfusion (I/R) injury in a model of middle cerebral artery occlusion and reperfusion (MCAO/R) in rats. The effects of schisandrin B were investigated with particular emphasis on TLR4 signal transduction and on the inflammatory response. Schisandrin B treatment conferred significant protection against MCAO/R injury, as evidenced by decreases in infarct volume, neurological score, and the number of apoptotic neurons and inflammatory signaling molecules.
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