Journal
NEURO-ONCOLOGY
Volume 22, Issue 9, Pages 1262-1275Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/noaa141
Keywords
cerebral blood volume; clinical trial; consensus protocol; DSC-MRI; high-grade glioma
Categories
Funding
- NIH [U01 CA176110, R01 CA 082500, R01 CA221938, R01 CA213158-01]
- Medical College of Wisconsin Cancer Center
- American Cancer Society (ACS) Research Scholar Grant [RSG15-003-01-CCE]
- American Brain Tumor Association (ABTA) Research Collaborators Grant [ARC1700002]
- National Brain Tumor Society (NBTS) Research Grant
- NIH/NCI UCLA Brain Tumor SPORE [1P50CA21101501A1]
- NIH/NCI [1R21CA223757-01]
- NATIONAL CANCER INSTITUTE [ZIABC011714, ZIDBC011642, ZIABC011643, ZIABC011647, ZIABC011640] Funding Source: NIH RePORTER
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Despite the widespread clinical use of dynamic susceptibility contrast (DSC) MRI, DSC-MRI methodology has not been standardized, hindering its utilization for response assessment in multicenter trials. Recently, the DSC-MRI Standardization Subcommittee of the Jumpstarting Brain Tumor Drug Development Coalition issued an updated consensus DSC-MRI protocol compatible with the standardized brain tumor imaging protocol (BTIP) for high-grade gliomas that is increasingly used in the clinical setting and is the default MRI protocol for the National Clinical Trials Network. After reviewing the basis for controversy over DSC-MRI protocols, this paper provides evidence-based best practices for clinical DSC-MRI as determined by the Committee, including pulse sequence (gradient echo vs spin echo), BTIP-compliant contrast agent dosing (preload and bolus), flip angle (FA), echo time (TE), and post-processing leakage correction. In summary, full-dose preload, full-dose bolus dosing using intermediate (60 degrees) FA and field strength-dependent TE (40-50 ms at 1.5T, 20-35 ms at 3T) provides overall best accuracy and precision for cerebral blood volume estimates. When single-dose contrast agent usage is desired, no-preload, full-dose bolus dosing using low FA (30 degrees) and field strength-dependent TE provides excellent performance, with reduced contrast agent usage and elimination of potential systematic errors introduced by variations in preload dose and incubation time.
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