Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 27, Issue 7, Pages 605-614Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41594-020-0438-0
Keywords
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Funding
- NIH [NCI R01CA214608, R01CA218278]
- Mark Foundation Emerging Leader Award
- Damon Runyon Cancer Research Foundation [DRR-50-18]
- Chleck Foundation fellowship
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Controlled perturbation of protein activity is essential to study protein function in cells and living organisms. Small molecules that hijack the cellular protein ubiquitination machinery to selectively degrade proteins of interest, so-called degraders, have recently emerged as alternatives to selective chemical inhibitors, both as therapeutic modalities and as powerful research tools. These systems offer unprecedented temporal and spatial control over protein function. Here, we review recent developments in this field, with a particular focus on the use of degraders as research tools to interrogate complex biological problems. Small molecules that hijack the cellular protein ubiquitination machinery to selectively degrade proteins of interest have emerged as therapeutic modalities and powerful research tools. This Review summarizes recent developments in this field, with a focus on the use of degraders as research tools.
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