Journal
NATURE REVIEWS GENETICS
Volume 21, Issue 11, Pages 699-714Publisher
NATURE RESEARCH
DOI: 10.1038/s41576-020-0254-8
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Funding
- CONACyT [576333]
- Universidad Nacional Autonoma de Mexico (UNAM)
- National Institutes of Health [5R01GM110597-04, 1RO1GM131643-01A1, R01GM077678]
- Galletti Endowment at UC San Diego
- BBSRC [BB/J006076/1] Funding Source: UKRI
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In this Expert Recommendation, the authors review the definitions of classic concepts relating to bacterial gene regulation, with a focus on transcription initiation, and suggest up-to-date, precise definitions to provide a reference for knowledge representation, modelling and future research on bacterial gene regulation. Despite enormous progress in understanding the fundamentals of bacterial gene regulation, our knowledge remains limited when compared with the number of bacterial genomes and regulatory systems to be discovered. Derived from a small number of initial studies, classic definitions for concepts of gene regulation have evolved as the number of characterized promoters has increased. Together with discoveries made using new technologies, this knowledge has led to revised generalizations and principles. In this Expert Recommendation, we suggest precise, updated definitions that support a logical, consistent conceptual framework of bacterial gene regulation, focusing on transcription initiation. The resulting concepts can be formalized by ontologies for computational modelling, laying the foundation for improved bioinformatics tools, knowledge-based resources and scientific communication. Thus, this work will help researchers construct better predictive models, with different formalisms, that will be useful in engineering, synthetic biology, microbiology and genetics.
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