Journal
NATURE PHOTONICS
Volume 14, Issue 7, Pages 452-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41566-020-0631-z
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Funding
- European Research Council under the European Union [640012]
- EPSRC [EP/P030017/1]
- RS Macdonald Charitable Trust
- Royal Society of Edinburgh (Biomedical Fellowship)
- British Heart Foundation [FS/17/9/32676]
- Wellcome Trust [204821/Z/16/A]
- European Commission (Marie Skodowska-Curie Individual Fellowship) [659213]
- Royal Society (Dorothy Hodgkin Fellowship) [DH160102, RGF\R1\180070]
- EPSRC [EP/P030017/1] Funding Source: UKRI
- Wellcome Trust [204821/Z/16/A] Funding Source: Wellcome Trust
- Marie Curie Actions (MSCA) [659213] Funding Source: Marie Curie Actions (MSCA)
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The incorporation of microdisk lasers into heart cells allows all-optical recording of cardiac contraction with cellular resolution. The contractility of cardiac cells is a key parameter that describes the biomechanical characteristics of the beating heart, but functional monitoring of three-dimensional cardiac tissue with single-cell resolution remains a major challenge. Here, we introduce microscopic whispering-gallery-mode lasers into cardiac cells to realize all-optical recording of transient cardiac contraction profiles with cellular resolution. The brilliant emission and high spectral sensitivity of microlasers to local changes in refractive index enable long-term tracking of individual cardiac cells, monitoring of drug administration, accurate measurements of organ-scale contractility in live zebrafish, and robust contractility sensing through hundreds of micrometres of rat heart tissue. Our study reveals changes in sarcomeric protein density as an underlying factor to cardiac contraction. More broadly, the use of novel micro- and nanoscopic lasers as non-invasive, biointegrated optical sensors brings new opportunities to monitor a wide range of physiological parameters with cellular resolution.
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