Journal
NATURE NANOTECHNOLOGY
Volume 15, Issue 11, Pages 941-+Publisher
NATURE RESEARCH
DOI: 10.1038/s41565-020-0755-9
Keywords
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Funding
- National Science Foundation [CMMI-1563422, DMR-1904576, CMMI-1562915]
- Department of Mechanical Engineering
- SBU-BNL SEED grant
- National Science and Technology Major Project from the Minister of Science and Technology of China [2018AAA0103100, 2020AAA0130100]
- National Natural Science Foundation of China [61574156, 61904187, 51703239, 51703238, 61605233]
- Scientific Instrument and Equipment Development Project of the Chinese Academy of Sciences [YJKYYQ20170060]
- National Science Fund for Excellent Young Scholars [61822406]
- Shanghai Outstanding Academic Leaders Plan [18XD1404700]
- Shanghai Sailing Program [19YF1456700, 17YF1422800]
- Key Research Program of Frontier Sciences, CAS [ZDBS-LY-JSC024]
- Youth Innovation Promotion Association CAS [2019236]
- Xinwei Star Project [Y91QDA1001]
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Nanoscale lithography and information storage in biocompatible materials offer possibilities for applications such as bioelectronics and degradable electronics for which traditional semiconductor fabrication techniques cannot be used. Silk fibroin, a natural protein renowned for its strength and biocompatibility, has been widely studied in this context. Here, we present the use of silk film as a biofunctional medium for nanolithography and data storage. Using tip-enhanced near-field infrared nanolithography, we demonstrate versatile manipulation and characterize the topography and conformation of the silk in situ. In particular, we fabricate greyscale and dual-tone nanopatterns with full-width at half-maximum resolutions of similar to 35 nm, creating an erasable 'silk drive' that digital data can be written to or read from. As an optical storage medium, the silk drive can store digital and biological information with a capacity of similar to 64 GB inch(-2) and exhibits long-term stability under various harsh conditions. As a proof-of-principle demonstration, we show that this silk drive can be biofunctionalized to exhibit chromogenic reactions, resistance to bacterial infection and heat-triggered, enzyme-assisted decomposition.
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