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NATURE CHEMICAL BIOLOGY (2016)
Editing the epigenome: technologies for programmable transcription and epigenetic modulation
Pratiksha I. Thakore et al.
NATURE METHODS (2016)
Targeted AIDID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells
Yunqing Ma et al.
NATURE METHODS (2016)
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells
Gaelen T. Hess et al.
NATURE METHODS (2016)
Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
Ming Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems
Keiji Nishida et al.
SCIENCE (2016)
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
Fuguo Jiang et al.
SCIENCE (2016)
Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases
Jean-Baptiste Renaud et al.
CELL REPORTS (2016)
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
Bernd Zetsche et al.
CELL (2015)
Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
Chen Yu et al.
CELL STEM CELL (2015)
Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems
Sergey Shmakov et al.
MOLECULAR CELL (2015)
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
Benjamin P. Kleinstiver et al.
NATURE (2015)
Conformational control of DNA target cleavage by CRISPR-Cas9
Samuel H. Sternberg et al.
NATURE (2015)
In vivo genome editing using Staphylococcus aureus Cas9
F. Ann Ran et al.
NATURE (2015)
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
Takeshi Maruyama et al.
NATURE BIOTECHNOLOGY (2015)
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
Benjamin P. Kleinstiver et al.
NATURE BIOTECHNOLOGY (2015)
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
Van Trung Chu et al.
NATURE BIOTECHNOLOGY (2015)
A split-Cas9 architecture for inducible genome editing and transcription modulation
Bernd Zetsche et al.
NATURE BIOTECHNOLOGY (2015)
Small molecule-triggered Cas9 protein with improved genome-editing specificity
Kevin M. Davis et al.
NATURE CHEMICAL BIOLOGY (2015)
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
Daesik Kim et al.
NATURE METHODS (2015)
High-throughput functional genomics using CRISPR-Cas9
Ophir Shalem et al.
NATURE REVIEWS GENETICS (2015)
An updated evolutionary classification of CRISPR-Cas systems
Kira S. Makarova et al.
NATURE REVIEWS MICROBIOLOGY (2015)
Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing
Jordan Pinder et al.
NUCLEIC ACIDS RESEARCH (2015)
A Cas9-guide RNA complex preorganized for target DNA recognition
Fuguo Jiang et al.
SCIENCE (2015)
Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing
Francis Robert et al.
GENOME MEDICINE (2015)
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
John A. Zuris et al.
NATURE BIOTECHNOLOGY (2015)
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Shengdar Q. Tsai et al.
NATURE BIOTECHNOLOGY (2015)
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
Hiroshi Nishimasu et al.
CELL (2014)
Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair
Thomas O. Auer et al.
GENOME RESEARCH (2014)
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
Sojung Kim et al.
GENOME RESEARCH (2014)
In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
Danilo Maddalo et al.
NATURE (2014)
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
Samuel H. Sternberg et al.
NATURE (2014)
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
Yanfang Fu et al.
NATURE BIOTECHNOLOGY (2014)
Dimeric CRISPR RNA-guided Fokl nucleases for highly specific genome editing
Shengdar Q. Tsai et al.
NATURE BIOTECHNOLOGY (2014)
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation
John G. Doench et al.
NATURE BIOTECHNOLOGY (2014)
Fusion of catalytically inactive Cas9 to Fokl nuclease improves the specificity of genome modification
John P. Guilinger et al.
NATURE BIOTECHNOLOGY (2014)
Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes
Mark D. Szczelkun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
Ophir Shalem et al.
SCIENCE (2014)
Genetic Screens in Human Cells Using the CRISPR-Cas9 System
Tim Wang et al.
SCIENCE (2014)
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
Martin Jinek et al.
SCIENCE (2014)
Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR-Cas9 system
R. Torres et al.
NATURE COMMUNICATIONS (2014)
Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9
Shota Nakade et al.
NATURE COMMUNICATIONS (2014)
Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
Steven Lin et al.
ELIFE (2014)
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
Haoyi Wang et al.
CELL (2013)
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
F. Ann Ran et al.
CELL (2013)
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu et al.
NATURE BIOTECHNOLOGY (2013)
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
Seung Woo Cho et al.
NATURE BIOTECHNOLOGY (2013)
Efficient genome editing in zebrafish using a CRISPR-Cas system
Woong Y. Hwang et al.
NATURE BIOTECHNOLOGY (2013)
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
Vikram Pattanayak et al.
NATURE BIOTECHNOLOGY (2013)
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Yanfang Fu et al.
NATURE BIOTECHNOLOGY (2013)
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
Kevin M. Esvelt et al.
NATURE METHODS (2013)
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
Zhonggang Hou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali et al.
SCIENCE (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
Repair of Strand Breaks by Homologous Recombination
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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression
Mrinal Srivastava et al.
CELL (2012)
Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
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MOLECULAR CELL (2012)
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
Giedrius Gasiunas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
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SCIENCE (2012)
Genome Engineering With Zinc-Finger Nucleases
Dana Carroll
GENETICS (2011)
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
Elitza Deltcheva et al.
NATURE (2011)
Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification
Barry L. Stoddard
STRUCTURE (2011)
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
Michael R. Lieber
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 (2010)
Regulation of Homologous Recombination in Eukaryotes
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ANNUAL REVIEW OF GENETICS, VOL 44 (2010)
Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
Michelle Christian et al.
GENETICS (2010)
The DNA Damage Response: Making It Safe to Play with Knives
Alberto Ciccia et al.
MOLECULAR CELL (2010)
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
Josiane E. Garneau et al.
NATURE (2010)
Triggers for genomic rearrangements: insights into genomic, cellular and environmental influences
Ram-Shankar Mani et al.
NATURE REVIEWS GENETICS (2010)
Genome editing with engineered zinc finger nucleases
Fyodor D. Urnov et al.
NATURE REVIEWS GENETICS (2010)
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors
Jens Boch et al.
SCIENCE (2009)
HIV-1 proviral DNA excision using an evolved recombinase
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SCIENCE (2007)
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
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NUCLEIC ACIDS RESEARCH (2003)
Chimeric nucleases stimulate gene targeting in human cells
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SCIENCE (2003)
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
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NATURE (2002)
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase
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MUTATION RESEARCH-DNA REPAIR (2000)
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