Qualitative analysis of the acetogenins fromAnnona coriacea(Annonaceae) leaves by HPLC-Q-Orbitrap and their antibacterial potential against oral pathogens

Araticum is an edible and appreciable fruit ofAnnona coriacea, which is popularly known as a traditional herb in the Brazilian cerrado. A phytochemical study from the leaves ofA. coriaceashowed that HPLC-ESI-Q-Orbitrap (R) provided through PRM experiments (MS2) is an efficient method for the fast and accurate analysis of a complex mixture of annonaceous acetogenins, with the identification of sylvaticin and gigantetrocin-A type acetogenins for the first time. In addition, the crude leaf extract and acetogenin-rich fractions were assayed againstStreptococcus mutans,S. mitis,S. sanguinisandS. salivariusstrains, which are usually related to oral infections.

Automated summary

Araticum, a traditional herb in the Brazilian cerrado, is an edible and appreciable fruit. A study found that HPLC-ESI-Q-Orbitrap (R) is an efficient method for analyzing the complex mixture of annonaceous acetogenins, and two specific compounds were identified for the first time. Additionally, the crude leaf extract and acetogenin-rich fractions showed inhibitory effects against oral infection-related bacteria.