A new steroidal alkaloid fromFritillaria michailovskyiFomin

A new steroidal alkaloid, michainine (1), was isolated fromFritillaria michailovskyiFomin, along with nine known compounds2-10of different classes, including ribonucleoside, steroids, and fatty acids, which were isolated for the first time from this plant. Their structures were elucidated through extensive spectroscopic techniques, as well as by comparing the data in the literature. Furthermore, the dichloromethane fraction ofF. michailovskyishowed a positive butyrylcholinesterase inhibitory activity, along with non-cytotoxicity against 3T3 cell line.

Automated summary

A new steroidal alkaloid michainine and nine known compounds were isolated from Fritillaria michailovskyi for the first time, including ribonucleosides, steroids, and fatty acids. Michainine showed positive inhibitory activity on butyrylcholinesterase and non-cytotoxicity against 3T3 cell line.