Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 1, Pages 287-294Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1779268
Keywords
Dibenzocyclooctadiene; lignan; Schisandra sphaerandra; Schisandraceae
Categories
Funding
- Science and Technology Plan Project of Zhejiang Province [LGF20H300010]
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Chemical investigation of the stems of medicinal plant Schisandra sphaerandra led to the discovery of a new lignan compound, along with 11 known lignans, with cytotoxic activity against triple-negative breast cancer cell lines MDA-MB-231 and HCC-1937. This study also identified the chemical structure of the new compound using comprehensive spectroscopic methods.
Chemical investigation into the stems of the medicinal plantSchisandra sphaerandraled to the isolation and identification of a new dibenzocyclooctadiene lignan sphaerandrin A (1) and 11 known ones gomisin B (2), schirubrisin B (3), kadsuphilin B (4), schizandrin (5), benzoylgomisin Q (6), angeloylgomisin Q (7), gomisin G (8), schisanwilsonin O (9), isogomisin O (10), schisantherin D (11), and wuweizisu C (12). The structure of the new compound was elucidated by comprehensive spectroscopic methods including 1 D/2D NMR, HRESIMS, and CD spectrometry. To the best of our knowledge, compounds2 - 11were obtained from this species for the first time. All the compounds were evaluated for the cytotoxic activity against the triple-negative breast cancer cell lines MDA-MB-231 and HCC-1937.
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