Dibenzocyclooctadiene lignans from the stems ofSchisandra sphaerandra

Chemical investigation into the stems of the medicinal plantSchisandra sphaerandraled to the isolation and identification of a new dibenzocyclooctadiene lignan sphaerandrin A (1) and 11 known ones gomisin B (2), schirubrisin B (3), kadsuphilin B (4), schizandrin (5), benzoylgomisin Q (6), angeloylgomisin Q (7), gomisin G (8), schisanwilsonin O (9), isogomisin O (10), schisantherin D (11), and wuweizisu C (12). The structure of the new compound was elucidated by comprehensive spectroscopic methods including 1 D/2D NMR, HRESIMS, and CD spectrometry. To the best of our knowledge, compounds2 - 11were obtained from this species for the first time. All the compounds were evaluated for the cytotoxic activity against the triple-negative breast cancer cell lines MDA-MB-231 and HCC-1937.

Automated summary

Chemical investigation of the stems of medicinal plant Schisandra sphaerandra led to the discovery of a new lignan compound, along with 11 known lignans, with cytotoxic activity against triple-negative breast cancer cell lines MDA-MB-231 and HCC-1937. This study also identified the chemical structure of the new compound using comprehensive spectroscopic methods.