Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 30, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.nano.2020.102281
Keywords
Magnetic targeting; Stress urinary incontinence; Cell transplantation; Adipose derived stem cells
Funding
- National Natural Science Foundation of China [81270780, 81800593, 81470917]
- Doctorate Innovation Fund of Shanghai Jiao Tong University School of Medicine [BXJ201943]
- The Belt and Road Young Scientist Communication International Cooperation Project [18410741600]
- Program for Outstanding Medical Academic Leader of Shanghai
- Sichuan Science Fund for Distinguished Young Scholars Incubation Program [19JCQN0083]
- Shanghai Outstanding Academic Leaders Plan [17XD1403100]
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Cell-based injectable therapy utilizing stem cells is a promising approach for the treatment of stress urinary incontinence (SUI). Applying a magnetically controlled cell delivery approach has enormous potential to enhance cell retention capability within the specified site. To assess the therapeutic efficacy of cellular magnetic targeting, we applied an external magnetic force to target an adipose-derived stem cell based therapy in a rat model of SUI. The results revealed that magnetic attraction of transplanted cells under the magnetic field was generated by cell uptake of superparamagnetic iron oxide nanoparticles in vitro. More importantly, magnetic targeting improved the retention rate of transplanted cells and facilitated the restoration of sphincter structure and function in a rat SUI model according to the results of histological examination and urodynamic testing. Therefore, magnetically guided targeting strategy might be a potential therapy method for treatment of SUI. (C) 2020 Elsevier Inc. All rights reserved.
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