Journal
NANOMEDICINE
Volume 15, Issue 18, Pages 1743-1761Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2020-0134
Keywords
alpha-terpineol; antivirulence; biofilms; nanoencapsulation; Pseudomonas aeruginosa; quorum sensing
Funding
- Indian Council of Medical Research (ICMR), New Delhi, India [3/1/3/JRF2014/HRD-82]
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Aim:Pseudomonas aeruginosahas emerged as a major opportunistic pathogen meaning there is an immediate need to develop efficient antivirulence agents which offer a new class of superior therapeutics.Methods:Nanostructured lipid carriers (NLCs) containing alpha-terpineol (alpha T) were developed and characterized to determine expression profiles of quorum sensing regulated genes, antivirulence activity and antibiofilm effects againstP. aeruginosa.Results:The alpha T-NLCs had a size of 145.4 nm, polydispersity index of 0.242 and zeta-potential of -31.4 mV. They exhibited pronounced effects on the inhibition of quorum sensing mediated virulence and biofilm formation which were confirmed by molecular docking analysis and gene expression profiles.Conclusion:alpha T-NLCs show promise as effective antivirulence agents againstP. aeruginosain the postantibiotic era. [GRAPHICS] .
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