Journal
NANOMEDICINE
Volume 15, Issue 14, Pages 1391-1409Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2020-0066
Keywords
brain tumor targeting; chemotherapy; RNA interference; synergistic efficiency; virus-like particle
Funding
- National Natural Science Foundation of China [U1904206, 31870994]
- Natural Science Foundation of Fujian Province of China [2018J01131]
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Aim: To explore the therapeutic effect of nanoparticle-based dual-targeting delivery of antitumor agents for glioblastoma treatment. Materials & methods: A hepatitis B core protein-virus-like particle (VLP)-based dual-targeting delivery system was designed with the primary brain targeting peptide TGN for blood-brain barrier penetration and tumor vascular preferred ligand RGD (arginine-glycine-aspartic acid) for glioblastoma targeting. Chemo- and gene-therapeutic agents of paclitaxel and siRNA were co-packaged inside the vehicle. Results: The results demonstrated efficient delivery of the packaged agents to invasive tumor sites. The combination of chemo- and gene-therapies demonstrated synergistic antitumor effects through enhancing necrosis and apoptosis, as well as being able to inhibit tumor invasion with minimal cytotoxicity. Conclusion: Our hepatitis B core-VLP-based dual-targeting delivery of chemo- and gene-therapeutic agents possesses a synergistic antitumor effect for glioblastoma therapy.
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